Ligand-based discovery of coronavirus main protease inhibitors using MACAW molecular embeddingsArticle Published on 2023-12-012022-11-15 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] 치료제, [키워드] antiviral properties binding affinity cells Cheminformatics Compound compounds conducted coronavirus dataset dose-dependent inhibition drug design Drug discovery evaluate half-maximal inhibitory concentration in silico inhibitor inhibitory effect ligand-based drug design M pro Machine learning. machine-learning molecular protease Protease inhibitor screened selected thought Toxicity Virtual screening virus infectivity [DOI] 10.1080/14756366.2022.2132486 PMC 바로가기
What are the long-term holistic health consequences of COVID-19 among survivors? An umbrella systematic reviewArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute COVID-19 acute phase acute respiratory syndrome affected conducted consequence coronavirus COVID-19 COVID-19 treatments demographic data determine eligibility criteria employment Epidemiology fatigue functional Health Impact individual Laboratory parameters memory Pandemics Participants physical Psychological psychological impacts Quality of life ranged Research respiratory symptoms Sample SARS Coronavirus screened survived Survivors systematic review systematic reviews variant virus virus classification. [DOI] 10.1002/jmv.28086 PMC 바로가기
Surveillance of SARS-CoV-2 in nine neighborhood sewersheds in Detroit Tri-County area, United States: Assessing per capita SARS-CoV-2 estimations and COVID-19 incidenceResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome Assessing Biomarker Biomarkers collected Community Comparisons Concentration coronavirus correlation COVID-19 COVID-19 burdens COVID-19 case COVID-19 incidence creatinine cumulative demographic characteristics demographics Detroit Detroit Tri-County area Epidemiology genomic indicate Infection N1 and N2 nine normalized parameter polymerase chain Population predict quantified reduced RNA concentration SARS-CoV-2 SARS-CoV-2 RNA normalization screened selected suggested the disease transcriptase wastewater Wastewater-based epidemiology with COVID-19 xanthine [DOI] 10.1016/j.scitotenv.2022.158350 [Article Type] Research article
Folic acid: a potential inhibitor against SARS-CoV-2 nucleocapsid protein엽산: SARS-CoV-2 뉴클레오캡시드 단백질에 대한 잠재적 억제제Article Published on 2022-12-012022-09-11 Journal: Pharmaceutical Biology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, [키워드] analysed Analysis antagonist antiviral effects antivirus association cellular Chinese Chinese medicine Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 Data analysis docking drug target experiment Folic acid Genes global pandemic Host hub genes identify inhibit inhibition inhibitor involved material mCherry mCherry expression mechanism molecular molecular docking network pharmacology Network pharmacology. Nucleocapsid phosphoprotein Phosphoprotein Protein Regulatory RNA interference RNAi SARS-CoV-2 SARS-CoV-2 N SARS-CoV-2 nucleocapsid screened shown target targets therapeutic target Traditional Traditional Chinese medicine virus [DOI] 10.1080/13880209.2022.2063341 PMC 바로가기 [Article Type] Article
Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern ItalyArticle Published on 2022-12-012022-11-15 Journal: Environmental research [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG association B.1 Brazil circulation collected COVID-19 database detectable anti-SARS-CoV-2 antibodies downloaded emergence evaluated Evidence group highlight IgA antibodies IgG and IgM IgM individual Infection investigated Italy Laboratory lombardy measles molecular Mutation oropharyngeal swab outbreak pandemic Patient patients PCR positive positive patient producing Rash reported retrospective RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2. screened sequence sequence information Sequencing Spread strain subjects Surveillance syndrome tested Urine virus Wuhan [DOI] 10.1016/j.envres.2022.113979 PMC 바로가기
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
Could red cell distribution width be used for predicting cardiac injury in neonates with COVID-19?Article Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Affect all age group calculated coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 pandemic COVID-19 cut-off value determine Diagnosis died Diseases distribution Fever group Hospitalization illness immature immunologically Inflammation Inflammatory Injury Laboratory life-threatening management nasopharyngeal swab sample Neonatal Neonate Neonates Newborn Patient PCR PCR-positive polymerase chain populations positive Prognosis prognostic prognostic biomarker Prognostic value Red cell Red cell distribution width SARS-CoV-2 SARS-COV-2 infection screened Sensitivity and specificity severe disease significantly higher syndrome systemic inflammatory the patient troponin level troponin levels troponin. were used [DOI] 10.1002/jmv.28050 PMC 바로가기
Variant-specific RT-qPCR for rapid screening of B.1.617 mutations in SARS-CoV-2Article Published on 2022-12-012022-11-15 Journal: The Libyan journal of medicine [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] B.1.617 B.1.617 lineage B.1.617.1 B.1.617.2 collected country Delta delta variant detect Diagnostic method evaluate kappa variant. L452R Libya Lineage multiplex RT-qPCR Mutation mutations new SARS-CoV-2 P681 PCR assay positive sample required RT- qPCR RT-qPCR RT-qPCR assay SARS-CoV-2 screened Sequencing Spread tested variant virus whole genome [DOI] 10.1080/19932820.2022.2121252 PMC 바로가기
Highly sensitive and rapid detection of SARS-CoV-2 via a portable CRISPR-Cas13a-based lateral flow assayArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome addition amplification approach assays clinical sample comparable component Concentration coronavirus disease Coronavirus-2 COVID-19 CRISPR Diagnostic method Effectiveness ENhance examined identify immunochromatographic IMPROVE individual isothermal lateral flow lateral flow assay lateral flow strip limit of detection molecular polymerase chain primer probe Protein provide Quality control reliability Result reverse transcription RNA RT-PCR SARS-CoV-2 screened sensitive detection. sensitivity significantly Spread tested virus detection [DOI] 10.1002/jmv.28096 PMC 바로가기
Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기